Ajay Manthripragada founded an independent office, based in Los Angeles, in 2014 after working with practices in Paris, Casablanca, New York, and San Francisco. His work has been exhibited at MoMA, Harvard, IIT, and Cersaie Bologna and published in domus, Cite, and Inscriptions: Architecture Before Speech, among others. In 2018, Manthripragada was nominated for the Mies Crown Hall Americas Prize (MCHAP) for best realized building in the Americas by an emerging practitioner.

Manthripragada teaches core design studios and seminars and advises thesis at the GSD. He was previously Assistant Professor at California Polytechnic State University, San Luis Obispo, and Wortham Fellow and Smith Visiting Critic at Rice University. He has also taught at UC Berkeley, RISD, and California College of the Arts. Manthripragada holds a Bachelor of Arts from UC Berkeley and a Master of Architecture from Princeton.